Thursday, July 21, 2011

HUGE NEWS!

I am excited to report that the results of the ASSIST study are about to be published, and you fans get a sneak peak at the abstract! :)

I am one of the 9 patients who got control, and one of the 7 who went on to stem cell transplant, just in case you are wondering about my 15 minutes. It's big news, and I think should be a game changer in the treatment of scleroderma. Due to these results, Dr. Burt has started a new study which does not include control, and is comparing two different types of non-myeloablative stem cell transplant.

The Lancet, Early Online Publication, 20 July 2011doi:10.1016/S0140-6736(11)60982-3Cite or Link Using DOI
Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomised phase 2 trial

Dr Richard K Burt MD a , Sanjiv J Shah MD b, Karin Dill MD c, Prof Thomas Grant FACR c, Prof Mihai Gheorghiade MD d, James Schroeder MD e, Prof Robert Craig MD f, Prof Ikuo Hirano MD f, Karin Marshall RN c, Eric Ruderman MD e, Borko Jovanovic PhD g, Francesca Milanetti MD a h, Sandeep Jain MRCP a, Kristin Boyce RN a, Amy Morgan CNP a, James Carr MD c, Prof Walter Barr MD e ‡
Summary

Background
Non-randomised studies of haemopoietic stem-cell transplantation (HSCT) in systemic sclerosis have shown improvements in lung function and skin flexibility but high treatment-related mortality. We aimed to assess safety and efficacy of autologous non-myeloablative HSCT in a phase 2 trial compared with the standard of care, cyclophosphamide.
Methods
In our open-label, randomised, controlled phase 2 trial, we consecutively enrolled patients at Northwestern Memorial Hospital (Chicago, IL, USA) who were aged younger than 60 years with diffuse systemic sclerosis, modified Rodnan skin scores (mRSS) of more than 14, and internal organ involvement or restricted skin involvement (mRSS <14) but coexistent pulmonary involvement. We randomly allocated patients 1:1 by use of a computer-generated sequence with a mixed block design (blocks of ten and four) to receive HSCT, 200 mg/kg intravenous cyclophosphamide, and 6·5 mg/kg intravenous rabbit antithymocyte globulin or to receive 1·0 g/m2 intravenous cyclophosphamide once per month for 6 months. The primary outcome for all enrolled patients was improvement at 12 months' follow-up, defined as a decrease in mRSS (>25% for those with initial mRSS >14) or an increase in forced vital capacity by more than 10%. Patients in the control group with disease progression (>25% increase in mRSS or decrease of >10% in forced vital capacity) despite treatment with cyclophosphamide could switch to HSCT 12 months after enrolment. This study is registered with ClinicalTrials.gov, number NCT00278525.
Findings
Between Jan 18, 2006, and Nov 10, 2009 we enrolled 19 patients. All ten patients randomly allocated to receive HSCT improved at or before 12 months' follow-up, compared with none of nine allocated to cyclophosphamide (odds ratio 110, 95% CI 14·04—∞; p=0·00001). Eight of nine controls had disease progression (without interval improvement) compared with no patients treated by HSCT (p=0·0001), and seven patients switched to HSCT. Compared with baseline, data for 11 patients with follow-up to 2 years after HSCT suggested that improvements in mRSS (p<0·0001) and forced vital capacity (p<0·03) persisted.
Interpretation
Non-myeloablative autologous HSCT improves skin and pulmonary function in patients with systemic sclerosis for up to 2 years and is preferable to the current standard of care, but longer follow-up is needed.
Funding
None

7 comments:

  1. Hi there - I love to come back to your site to see how things are going! I had the immunoablative high-dose cyclophosphamide without the stem-cell transplant - as part of the Johns Hopkins HiCy program - back in April. So far the skin and muscle recovery is incredible. And I'm finally getting my hair back again...

    ReplyDelete
  2. Awesome!!! Now we need more funding...

    ReplyDelete
  3. I am happy to share with the world because there are lots of doubts about the cure of Scleroderma disease, but now I have to believe that the miracle I received may be useful to the world and the victims of Scleroderma. My name is Harriet Kaur I lived with this deadly disease for over a year, my husband discovered that we were both Scleroderma positive. We try by all means to live our lives using anti retro viral Drugs, in spite of this thing in our body we were always unhappy, until we stumbled upon this powerful herbalist who portrayed healing. At first we were skeptical, but my husband insisted on giving it a try and ask some of the herbs shipped in for us, and a few weeks after the completion of the process due to this herbalist help, we went to test after taking the herbs for few weeks, we were crushed with joy we received results in the hospital from our family doctor. The rate of virus in the body within a few weeks had dropped, we were completely healed. The herbalist explained that he did not publish to the world because he had been refused in 2011, by the international research team because he uses a traditional means to cure patients. The most important thing is for you to be cured, if you want to know about this herbalist email him: SACREDSPELLTEMPLE@HOTMAIL.COM or add him on whatsapp +2348079540032. you can email me also for more information harrietkaur1@gmail.com.

    ReplyDelete
  4. I am happy to share with the world because there are lots of doubts about the cure of Scleroderma disease, but now I have to believe that the miracle I received may be useful to the world and the victims of Scleroderma. My name is Harriet Kaur I lived with this deadly disease for over a year, my husband discovered that we were both Scleroderma positive. We try by all means to live our lives using anti retro viral Drugs, in spite of this thing in our body we were always unhappy, until we stumbled upon this powerful herbalist who portrayed healing. At first we were skeptical, but my husband insisted on giving it a try and ask some of the herbs shipped in for us, and a few weeks after the completion of the process due to this herbalist help, we went to test after taking the herbs for few weeks, we were crushed with joy we received results in the hospital from our family doctor. The rate of virus in the body within a few weeks had dropped, we were completely healed. The herbalist explained that he did not publish to the world because he had been refused in 2011, by the international research team because he uses a traditional means to cure patients. The most important thing is for you to be cured, if you want to know about this herbalist email him: SACREDSPELLTEMPLE@HOTMAIL.COM or add him on whatsapp +2348079540032. you can email me also for more information harrietkaur1@gmail.com.,

    ReplyDelete
  5. Hi Friends i am so glad to write this article today to tell the world how Dr Ekpiku cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr Ekpiku the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: ekpikuspellhomeofgrace@gmail.com i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr Ekpiku that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via: ekpikuspellhomeofgrace@hotmail.com or whatapps, call +2348073673757.

    ReplyDelete
  6. Thanks for share this post....!

    http://www.herbs-solutions-by-nature.com/Scleroderma.php

    ReplyDelete
  7. Scleroderma is autoimmune disease in which your own immune system targets the connective tissues of the body. There's little scientific evidence to support the use of alternative medicine in treatment of scleroderma. Herbal Remedies of Scleroderma may be useful for individuals looking to manage this condition.

    ReplyDelete